Archive for the tag "PrEP"

The last word in HIV prevention (and farewell for now) (25/10/11)

Much has been going on in the world of HIV, sex and drugs in the last month or so; the US marines recruiting at gay community centers, more mysteriously disappointing study outcomes for PrEP, encouraging news about the effect of microbicide gels against herpes, a new super-easy condom with a brand name that will put […]

PrEP makes no sense for discordant couples – corrected (15/07/11)

First PReP worked for gay men, and we were happy. Then it didn’t work for straight women, and we were sad. Now, two big studies in heterosexuals have shown it can work for straight couples, and we are deeply confused. Or at least I am. Taking anti-HIV pills every day cuts the risk of infection […]

The PReP roller-coaster: no good for women? (22/04/11)

Just as we were getting all excited about giving people antiretorvirals to protect them against HIV infection, a large trial of pre-exposure prophylaxis (PReP) in women is being shut down because the pills are unlikely to prevent HIV. It’s a huge disappointment to those who were hoping that the pill-a-day-to-avoid-a-pill-a-day solution might drag us out […]

PrEP works: Now what? (24/11/10)

It´s official. Taking antiretroviral drugs when you don´t have HIV cuts the risk that you´ll get infected. It´s exciting news, if not unexpected. But it´s going to be a major headache for politicians. The results of the iPrEx trial, were published today in the New England Journal of Medicine (with pdf but not the supplementary […]

Is CDC’s HIV prevention trial in Thailand ethical? (24/01/10)

How ethical are HIV prevention trials? Every time we announce results of a trial that compares new HIV infections in a group with or without some new intervention (a microbicide for example, or a vaccine), some journalist or other jumps on the fact that researchers are just watching people get infected. Researchers then explain that […]

Significant progress in HIV prevention (10/02/09)

Halleluliah! We’ve finally got something to be happy about in HIV prevention — a microbicide that cuts the risk of HIV infection by a third. You’d think everyone would be shouting for joy. But no, we’re bending over backwards to say we’re not sure it works. The product in question is Pro2000 gel, and the […]

Prepped for PrEP: are we ahead of ourselves? (24/11/08)

When I’m asked: What’s the next big thing in HIV prevention? I usually put Pre-Exposure Prophylaxis somewhere high on the list. We don’t yet know if giving out expensive drugs so that people can have unprotected sex without worrying about HIV will work. But I usually ask people to imagine the headlines in The Daily […]

To inform or to (over)protect? The Swiss have chosen well (05/02/08)

I’ve been taken to task for not weighing in on the kerfuffle about whether people on ARVs can pass on HIV. In case you haven’t been following the debate, the Swiss AIDS Commission has reviewed studies of couples where one partner has HIV and the other doesn’t, and has looked at HIV transmission with and […]

And another thing from those sensible Swiss (05/02/08)

Buried in the controversial Swiss report on HIV treatment and transmission of the virus is a nugget about initiating treatment. (French report here, unofficial English translation here) They say that antiretrovirals should only be given when it is medically indicated, and not to prevent the onward transmission of HIV in discordant couples. Two reasons: in […]

A viagra, half an E, some ARVs: the new party pack? (23/01/08)

So if you give antiretrovirals to humanised mice (don’t ask) and then slosh their vaginas full of HIV, they don’t get infected, according to a new study from Paul Denton and colleagues at the University of Texas. None of the five mice treated with a combination of emtricitabine and tenofovir got infected, whereas 7 out […]